Demonstrates improved neuroprotection and angiogenesis in ischemic stroke, suggesting new treatment strategies.
, the EBP-bFGF/ECM/TIMP-AMP hydrogel was transplanted into ischemic brain following IS. The findings indicated that the application of the innovative EBP-bFGF/ECM/TIMP-AMP hydrogel facilitated the preservation of neuronal integrity and conferred potent neuroprotection. Additionally, the therapeutic intervention significantly stimulated angiogenesis and achieved stabilization of the blood brain barrier through inhibition of MMP-2 overactivity, thereby diminishing vascular permeability. Collectively, these findings establish the targeted, stimulus-responsive co-delivery of bFGF and TIMP-AMP as a promising regenerative strategy, which orchestrates neuroprotection, angiogenesis, and BBB stabilization to synergistically promote repair and recovery after ischemic stroke.
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Wang et al. (2026) studied this question.
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