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May 9, 2026Advanced ScienceOpen Access

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

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Authors

SYSha YuUniversity of SouthamptonBBayinqiaogeUniversity of SouthamptonXLXi LuUniversity of Southampton

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Implication

Review summarizes advances in metabolism-based biomarkers for rapid susceptibility testing in bacteria, suggesting improved methods for tackling antibiotic resistance.

Key Points

  • This review aims to highlight the potential of metabolism-based biomarkers in accelerating the process of antibiotic susceptibility testing.
  • Summarized the latest advancements in metabolism-based biomarkers for antibiotic susceptibility testing.
  • Discussed the influence of antibiotics on bacterial metabolism and linked resistance mechanisms to metabolic activities.
  • Categorized metabolic biomarkers based on physiological processes such as nutrient uptake and enzymatic function.
  • Identified key metabolic activities influenced by antibiotics that can serve as rapid indicators of susceptibility.
  • Outlined challenges in developing deployable metabolism-based AST platforms and future directions for research.

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/69fed16ab9154b0b82878b9dhttps://doi.org/10.1002/advs.75553
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