Randomized trial evaluates how type I interferon affects anergy in CD8 T cells, suggesting new insights into autoimmunity.
CD8 T cell subset that can contribute to a pathogen-specific immune response. Collectively, our results suggest that elevated basal IFN-I levels limit anergy induction, providing a potential mechanistic explanation for the association of baseline inflammation with the development of autoimmunity.
No takes yet. Share an insight, caveat, or question.
Haefke et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: