DA5‐CH and Semaglutide Protect against Neurodegeneration and Reduce α‐Synuclein Levels in the 6‐OHDA Parkinson’s Disease Rat Model

phosphorylation was also attenuated after drug treatment, with DA5-CH being more effective. Therefore, while semaglutide showed good effects in this PD model, DA5-CH was superior and may be a better therapeutic drug for neurodegenerative disorders such as PD than GLP-1 receptor agonists that do not easily cross the BBB.