What question did this study set out to answer?

To develop and validate an experimental animal model for peripheral neuropathic pain using tight segmental spinal nerve ligation.

September 1, 1992Pain

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

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Authors

SKSun Ho KimGyeongsang National University JCJin Mo ChungSemmelweis University

Discussion

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Implication

Preclinical study demonstrates segmental spinal nerve ligation induces persistent thermal hyperalgesia and mechanical allodynia in rats, indicating a reproducible model for human causalgia.

Key Points

To develop and validate an experimental animal model for peripheral neuropathic pain using tight segmental spinal nerve ligation.
Rats received unilateral tight ligation of the L5 and L6 spinal nerves (group 1), L5 alone (group 2), or partial tight sciatic nerve ligation (group 3) under sodium pentobarbital anesthesia.
Paw withdrawal latency to radiant heat, mechanical sensitivity via von Frey filaments, and spontaneous pain behaviors were assessed for up to 16 weeks post-surgery.
Ligation in all groups induced long-lasting hyperalgesia to noxious heat persisting for at least 5 weeks.
Mechanical allodynia persisted for at least 10 weeks across all cohorts alongside behavioral signs of spontaneous pain in the affected foot.
The model established complete anatomical separation between injured and intact spinal segments, enabling targeted investigation of nerve injury mechanisms.

Cite This Study

Kim et al. (1992) studied this question.

synapsesocial.com/papers/69ff4b24e92f4a033c85247e https://doi.org/10.1016/0304-3959(92)90041-9

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September 1, 1992Pain

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

View Full Paper

Ask AI

Bookmark

Authors

SKSun Ho KimGyeongsang National University JCJin Mo ChungSemmelweis University

Discussion

Member takes

Implication

Preclinical study demonstrates segmental spinal nerve ligation induces persistent thermal hyperalgesia and mechanical allodynia in rats, indicating a reproducible model for human causalgia.

Key Points

To develop and validate an experimental animal model for peripheral neuropathic pain using tight segmental spinal nerve ligation.
Rats received unilateral tight ligation of the L5 and L6 spinal nerves (group 1), L5 alone (group 2), or partial tight sciatic nerve ligation (group 3) under sodium pentobarbital anesthesia.
Paw withdrawal latency to radiant heat, mechanical sensitivity via von Frey filaments, and spontaneous pain behaviors were assessed for up to 16 weeks post-surgery.
Ligation in all groups induced long-lasting hyperalgesia to noxious heat persisting for at least 5 weeks.
Mechanical allodynia persisted for at least 10 weeks across all cohorts alongside behavioral signs of spontaneous pain in the affected foot.
The model established complete anatomical separation between injured and intact spinal segments, enabling targeted investigation of nerve injury mechanisms.

Cite This Study

Kim et al. (1992) studied this question.

synapsesocial.com/papers/69ff4b24e92f4a033c85247e https://doi.org/10.1016/0304-3959(92)90041-9

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