Why the study?
Does preclinical cardiac electrophysiology data predict the risk of torsade de pointes in clinical use?
Population
100 drugs with published data on hERG (or I) activity, cardiac action potential duration, and QT…
Design
Review
Authors
Loading...
Provisional 30-fold hERG margins may inform TdP risk assessment in development; leaves open prospective clinical validation.
Does preclinical cardiac electrophysiology data predict the risk of torsade de pointes in clinical use?
A 30-fold margin between C(max) and hERG IC(50) may provide a provisional safety margin against torsade de pointes in drug development.
REDFERN et al. (2003) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: