A Matter of Life or Death: Productively Infected and Bystander CD4 T Cells in Early HIV Infection

Dechao Cao; Sushant Khanal; Ling Wang; Zhengke Li; Juan Zhao; Lam Nhat Nguyen; Lam Ngoc Thao Nguyen; Xindi Dang; Madison Schank; Bal Krishna Chand Thakuri; Jinyu Zhang; Zeyuan Lu; Xiao Y. Wu; Zheng D. Morrison; Mohamed El Gazzar; Shunbin Ning; Jonathan P. Moorman; Zhi Q. Yao

doi:10.3389/fimmu.2020.626431

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Abstract

cells, and rescued telomerase and AKT activities by inhibiting cell activation, HIV infection, and DDR. These results indicate that productively infected and bystander CD4 T cells employ different mechanisms for their survival and death, suggesting a possible pro-survival, pro-reservoir mechanism during early HIV infection.

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Cao et al. (2021) studied this question.

synapsesocial.com/papers/69ff5616831589f3542d84f7 https://doi.org/10.3389/fimmu.2020.626431

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A Matter of Life or Death: Productively Infected and Bystander CD4 T Cells in Early HIV Infection

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A Matter of Life or Death: Productively Infected and Bystander CD4 T Cells in Early HIV Infection

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