Assay development study demonstrates sub-femtomolar prostate-specific antigen detection in human serum, highlighting improved cancer monitoring after prostatectomy.
, 800 aM). The single molecule ULISA shows excellent correlation with an electrochemiluminescence reference method. Although the analogue readout can routinely measure PSA concentrations in human serum samples, very low concentrations have to be monitored after radical prostatectomy. Combining the digital and analogue readout covers a dynamic range of more than 3 orders of magnitude in a single experiment.
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Mickert et al. (2019) studied this question.
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