What question did this study set out to answer?

To investigate whether dioscin can protect against crystalline silica-induced pulmonary fibrosis and to elucidate its underlying cellular and molecular mechanisms in mice.

January 1, 2017TheranosticsOpen Access

Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice

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Authors

CLChao LiEli Lilly (United States)YLYiping LuEast China University of Science and Technology SDSitong DuJilin Agricultural University

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Implication

Preclinical study demonstrates that dioscin attenuates silica-induced lung inflammation and fibrosis in mice, suggesting its potential as a therapeutic candidate for silicosis.

Key Points

To investigate whether dioscin can protect against crystalline silica-induced pulmonary fibrosis and to elucidate its underlying cellular and molecular mechanisms in mice.
Administered crystalline silica to induce pulmonary fibrosis in mice, followed by oral gavage of dioscin initiated either 1 day (preventative) or 10 days (therapeutic for established fibrosis) post-instillation.
Evaluated macrophage and fibroblast responses in vitro using RAW264.7 and NIH-3T3 cell lines.
Dioscin reduced infiltration of macrophages, B lymphocytes, and T lymphocytes into lung tissue and suppressed pro-inflammatory and pro-fibrotic cytokine production.
Treatment inhibited TGF-β/Smad3 signaling, blocked phosphorylation of ASK1-p38/JNK and Smad3, and prevented fibrocyte recruitment and fibroblast activation.
Oral administration begun 10 days post-exposure significantly delayed the progression of established silicosis.

Cite This Study

Li et al. (2017) studied this question.

synapsesocial.com/papers/69ff73f22ff633f365778830 https://doi.org/10.7150/thno.20270

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Implication

Preclinical study demonstrates that dioscin attenuates silica-induced lung inflammation and fibrosis in mice, suggesting its potential as a therapeutic candidate for silicosis.

Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice

Discussion

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Implication

Key Points

Cite This Study

Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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