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This research aims to determine whether a unique set of outcome-predictive genes exists for breast cancer.

August 12, 2004BioinformaticsOpen Access

Outcome signature genes in breast cancer: is there a unique set?

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This research aims to determine whether a unique set of outcome-predictive genes exists for breast cancer.
Analyzed a single breast cancer dataset using methods from van't Veer et al.
Investigated the influence of patient subsets on gene selection and predictive outcomes.
Identified that the resulting list of predictive genes is not unique and varies by patient subset.
Found that many genes correlate with survival, but differences in these correlations are minimal.
Observed strong fluctuations in correlations across different patient groups.

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Randomized trial examines gene expression profiles in breast cancer, suggesting variability in outcomes based on patient selection.

Ein‐Dor et al. (2004) studied this question.

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