Synthesis with Perfect Atom Economy: Generation of Diazo Ketones by 1,3‐Dipolar Cycloaddition of Nitrous Oxide at Cyclic Alkynes under Mild Conditions

A cascade of five steps, transforms cyclooctynes in the presence of nucleophiles NuH and nitrous oxide, into the depicted products (see scheme). In another example, nitrous oxide was added at a cycloalkyne at −25 °C to generate the corresponding diazo ketone. In both cases, all three atoms of nitrous oxide were incorporated into the products. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.