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October 6, 2003Proceedings of the National Academy of SciencesOpen Access

Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction

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Population

Adult heart-derived cardiac progenitor cells expressing stem cell antigen-1; Cre/Lox donor/recipient pair…

Design

Preclinical

Authors

HOHidemasa OhSeoul National University Bundang HospitalSBSteven B. BradfuteNew Mexico Department of HealthTGTeresa D. GallardoUniversité Paris-Sud

Discussion

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Implication

Hypothesis-generating for cardiac progenitor therapy; leaves open translation to human myocardial repair.

Structured PICO

P
Population
Adult heart-derived cardiac progenitor cells expressing stem cell antigen-1; Cre/Lox donor/recipient pair (alphaMHC-Cre/R26R) mouse model of ischemia/reperfusion
I
Intervention
Intravenous administration of cardiac stem cell antigen 1 cells after ischemia/reperfusion; in vitro treatment with 5'-azacytidine
O
Outcome
Homing to injured myocardium, differentiation, and fusion to host cells

Adult heart-derived cardiac progenitor cells can home to injured myocardium and differentiate into cardiomyocytes both with and without fusing to existing host cells.

Cite This Study

Oh et al. (2003) studied this question.

synapsesocial.com/papers/69ff76c66018b8d0892d82e1https://doi.org/10.1073/pnas.2132126100
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