Does cynaroside inhibit doxorubicin-induced cardiomyocyte pyroptosis?
Cynaroside may offer a therapeutic approach to prevent doxorubicin-induced cardiomyopathy by inhibiting cardiomyocyte pyroptosis via the AMPK/SIRT3/Nrf2 pathway.
). We attribute it to the mediation of AMPK/SIRT3/Nrf2 pathway, which plays a central role in preventing DOX-induced cardiomyocyte injury. In conclusion, the present study confirms the therapeutic potential of Cyn in DIC by regulating the AMPK/SIRT3/Nrf2 pathway.
Zou et al. (Sun,) studied this question.