What question did this study set out to answer?

The aim is to explore the recruitment of regulatory T lymphocytes to prevent inflammation-related bone loss in periodontal disease.

Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes

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Randomized trial demonstrates reduced inflammation and bone loss in periodontal disease via regulatory T cell recruitment.

The aim is to explore the recruitment of regulatory T lymphocytes to prevent inflammation-related bone loss in periodontal disease.
Developed a controlled release system using a polymer to deliver CCL22.
Administered the formulation in murine experimental periodontitis and ligature-induced periodontitis in beagle dogs.
Measured levels of Treg-associated anti-inflammatory molecules and cytokines.
Increased anti-inflammatory molecules and decreased proinflammatory cytokines in murine periodontitis.
Marked reduction in alveolar bone resorption observed in treated mice.
Beagle dogs exhibited reduced inflammation and less alveolar bone loss after treatment with human CCL22.

Glowacki et al. (2013) studied this question.

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