What question did this study set out to answer?

This research aims to explore the relationship between repetitive negative thinking (RNT) and Alzheimer's disease (AD) biomarkers.

June 7, 2020Alzheimer s & DementiaOpen Access

Repetitive negative thinking is associated with amyloid, tau, and cognitive decline

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Authors

NMNatalie L. MarchantUniversité Claude Bernard Lyon 1 LLLise R. LovlandThe London College RJRebecca JonesBrigham Young University

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Implication

Randomized trial reveals associations of repetitive negative thinking with cognitive decline and AD biomarkers in older adults, suggesting potential intervention avenues.

Key Points

This research aims to explore the relationship between repetitive negative thinking (RNT) and Alzheimer's disease (AD) biomarkers.
Analyzed data from 292 older adults, including cognitive assessments and RNT questionnaires.
Used amyloid-PET and tau-PET scans to assess AD markers.
Included participants from PREVENT-AD and IMAP+ cohorts.
RNT was significantly associated with global cognition decline (P = .02).
Memory decline was evidenced with immediate (P = .03) and delayed memory (P = .04).
RNT correlated with global amyloid (P = .01 for PREVENT-AD; P = .03 for IMAP+) and entorhinal tau deposition (P = .02).

Cite This Study

Marchant et al. (2020) studied this question.

synapsesocial.com/papers/69ff89b4b124fe5819857cc3 https://doi.org/10.1002/alz.12116

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Implication

Randomized trial reveals associations of repetitive negative thinking with cognitive decline and AD biomarkers in older adults, suggesting potential intervention avenues.

Repetitive negative thinking is associated with amyloid, tau, and cognitive decline

Discussion

Member takes

Implication

Key Points

Cite This Study

Repetitive negative thinking is associated with amyloid, tau, and cognitive decline

Discussion

Member takes

Implication

Key Points

Cite This Study

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