AIMS: associated with obesity across a series of drugs. METHODS: (HPLC)), and the octanol-water partition coefficient (LogP). RESULTS: = .62). CONCLUSION: of drugs in obese patients. The consequent prolongation of half-life in obesity has clinical safety implications in terms of delayed drug accumulation and washout during and after chronic dosage. The magnitude and importance of this effect for a given drug depends on the degree of obesity, as well as the lipid-solubility of the specific drug.
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Bruno et al. (2021) studied this question.
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