Why the study?
Low 25-hydroxyvitamin D levels have been associated with higher late-life depression risk, but few long-term, high-dose large-scale trials existed.
Does vitamin D3 supplementation prevent depression or clinically relevant depressive symptoms in adults aged 50 years or older?
Does vitamin D3 supplementation prevent depression or clinically relevant depressive symptoms in adults aged 50 years or older?
Long-term vitamin D3 supplementation does not prevent depression or improve mood scores in older adults.
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Vitamin D3 supplementation does not prevent depression in adults ≥50 years; confirms null primary endpoint in this large RCT.
Okereke et al. (2020) studied this question.
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