What question did this study set out to answer?

To review the epidemiology, clinical dilemmas, and emerging therapeutic options for multidrug-resistant gram-negative bacterial infections in hospital settings.

February 11, 2016Microbial Drug Resistance

Multidrug-Resistant Gram-Negative Bacterial Infections in the Hospital Setting: Overview, Implications for Clinical Practice, and Emerging Treatment Options

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To review the epidemiology, clinical dilemmas, and emerging therapeutic options for multidrug-resistant gram-negative bacterial infections in hospital settings.
Narrative synthesis of hospital-acquired multidrug-resistant (MDR) gram-negative pathogens, focusing on Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Analysis of resistance drivers, empiric broad-spectrum antibiotic selection, and novel antimicrobial agents in development.
MDR gram-negative pathogens are widespread across US hospitals, driven by antimicrobial overuse, deficient stewardship, and suboptimal infection control.
Empiric management of critically ill patients warrants initial broad-spectrum coverage followed by rapid de-escalation once microbiological profiles are confirmed.
Novel antimicrobial options—including tigecycline, ceftolozane-tazobactam, and ceftazidime-avibactam—provide potent activity against resistant gram-negative strains.

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Implication

Clinical review reveals rising multidrug-resistant gram-negative infections in hospitalized patients, highlighting the urgent need for stewardship and novel therapies.

Cite This Study

Cerceo et al. (2016) studied this question.

synapsesocial.com/papers/69ff8fc4581c6e761e777960 https://doi.org/10.1089/mdr.2015.0220

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Implication

Clinical review reveals rising multidrug-resistant gram-negative infections in hospitalized patients, highlighting the urgent need for stewardship and novel therapies.

Multidrug-Resistant Gram-Negative Bacterial Infections in the Hospital Setting: Overview, Implications for Clinical Practice, and Emerging Treatment Options

Key Points

Discussion

Implication

Cite This Study

Multidrug-Resistant Gram-Negative Bacterial Infections in the Hospital Setting: Overview, Implications for Clinical Practice, and Emerging Treatment Options

Key Points

Discussion

Implication

Cite This Study

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