Why the study?
Although evidence implicates IL-33 and ST2 in heart remodeling, the molecular mechanism and effects of ST2 via the IL-33/ST2 axis in chronic heart failure needed delineation.
Does ST2 silencing aggravate ventricular remodeling and chronic heart failure in rats?
Population
Rats with chronic heart failure simulated by coronary artery ligation
Comparison
ST2 silencing and IL-33 overexpression
Design
Animal experimental study
Authors
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ST2 may protect against remodeling in experimental HF; animal data leaves open therapeutic targeting of the IL-33/ST2 axis in patients.
Does ST2 silencing aggravate ventricular remodeling and chronic heart failure in rats?
ST2 silencing aggravates ventricular remodeling and cardiac dysfunction in a rat model of heart failure by blocking the IL-33/ST2 axis.
Zhao et al. (2020) studied this question.
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