Why the study?
What are the frequency, predictors, and prognosis of intracranial hemorrhage associated with oral anticoagulation?
Population
Patients receiving oral anticoagulation, particularly elderly, stroke-prone patients
Design
Review
Authors
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Supports weighing ischemic benefits against ~1%/y ICH risk before anticoagulation; leaves open optimal intensity and patient selection.
What are the frequency, predictors, and prognosis of intracranial hemorrhage associated with oral anticoagulation?
Oral anticoagulation increases the risk of intracranial hemorrhage 7- to 10-fold, emphasizing the need to carefully weigh the absolute reduction in ischemic stroke against the risk of hemorrhage, particularly in elderly patients.
Hart et al. (1995) studied this question.
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