Experimental study demonstrates that lactate inhibits glucagon secretion in mouse and human islets, indicating that lactate modulates alpha-cell function.
OBJECTIVE: handling and GCG secretion. METHODS: currents, and GCG secretion. RESULTS: influx resulted in reduced GCG secretion in mouse (62 ± 6%) and human (43 ± 13%) islets. CONCLUSIONS: , and inhibition of GCG secretion. Thus, taken together, these data indicate that lactate either within α-cells and/or elevated in serum could serve as important modulators of α-cell function.
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Zaborska et al. (2020) studied this question.
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