Why the study?
Does task2 gene inactivation reduce renal bicarbonate reabsorption and cause metabolic acidosis in mice?
Population
task2 -/- mice backcrossed to C57BL6
Comparison
task2 gene inactivation (knockout model) vs control mice
Design
Preclinical
Authors
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TASK2 knockout models proximal renal tubular acidosis in mice; leaves open its validation and therapeutic targeting in humans.
Does task2 gene inactivation reduce renal bicarbonate reabsorption and cause metabolic acidosis in mice?
TASK2 K+ channel activity is specifically coupled to HCO3- transport, and its deficiency in mice mimics human proximal renal tubular acidosis syndrome.
Warth et al. (2004) studied this question.
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