Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1999AJP Renal Physiology

Two types of K+channels at the basolateral membrane of proximal tubule: inhibitory effect of taurine

View Full Paper
Ask AI
Bookmark
Share

Population

Rabbit proximal convoluted tubule cells

Comparison

Extracellular perfusion of 40 mM taurine vs Absence of taurine

Design

Preclinical

Authors

JNJean-François NoulinUniversité de SherbrookeEBEmmanuelle BrochieroCentre Hospitalier de l’Université de MontréalJLJean‐Yves LapointeUniversité de Montréal

Discussion

Loading...

Member takes

Implication

May alter proximal tubule K+ conductance in models; leaves open human translation or therapeutic relevance.

Structured PICO

P
Population
Rabbit proximal convoluted tubule cells
I
Intervention
Extracellular perfusion of 40 mM taurine
C
Comparator
Absence of taurine
O
Outcome
Potassium channel open probability (P(o)) and conductancesurrogate

Taurine decreases the basolateral absolute potassium conductance in rabbit proximal tubules specifically by inhibiting the ATP-blockable K channel.

Cite This Study

Noulin et al. (1999) studied this question.

synapsesocial.com/papers/6a97432cc3caee290889aaa6https://doi.org/10.1152/ajprenal.1999.277.2.f290
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A potassium channel in the apical membrane of rabbit thick ascending limb of Henle's loop1990 · 114 citations
  2. 2Na+ pump inhibition downregulates an ATP-sensitive K+ channel in rabbit proximal convoluted tubule1993 · 67 citations
  3. 3Low-conductance K channels in apical membrane of rat cortical collecting tubule1989 · 193 citations
  4. 4Regulation of basolateral K channels in proximal tubule studied during continuous microperfusion1993 · 63 citations