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September 1, 1987AJP Renal Physiology

Basolateral potassium channels in renal proximal tubule

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Population

Unperfused Necturus proximal tubules (basolateral membrane)

Design

Preclinical

Authors

HSHenry SackinRosalind Franklin University of Medicine and ScienceLPLawrence G. PalmerCornell University

Discussion

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Overview

Voltage-gated short open-time K+ channels may modulate proximal tubule transport; hypothesis-generating for mammalian renal physiology and leaves open clinical translation.

Structured PICO

P
Population
Unperfused Necturus proximal tubules (basolateral membrane)
I
Intervention
Patch-clamp techniques (cell-attached and excised patches)
O
Outcome
Kinetics, conductance, and voltage gating of basolateral potassium channelssurrogate

This basic science study characterizes the kinetics and voltage-gating properties of two distinct potassium channels in the basolateral membrane of Necturus proximal tubules.

Cite This Study

Sackin et al. (1987) studied this question.

synapsesocial.com/papers/6a887485aadaab60564fd352https://doi.org/10.1152/ajprenal.1987.253.3.f476
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of small-conductance K+ channel in apical membrane of rat cortical collecting tubule1990 · 226 citations
  2. 2Calcium‐activated potassium channels in single smooth muscle cells of rabbit jejunum and guinea‐pig mesenteric artery.1986 · 303 citations
  3. 3A calcium-permeable stretch-activated cation channel in renal proximal tubule1991 · 99 citations
  4. 4Two types of K+channels at the basolateral membrane of proximal tubule: inhibitory effect of taurine1999 · 26 citations
  5. 5Patch‐clamp studies of slow potential‐sensitive potassium channels in longitudinal smooth muscle cells of rabbit jejunum1983 · 101 citations