What question did this study set out to answer?

July 1, 1983The Journal of PhysiologyOpen Access

Patch‐clamp studies of slow potential‐sensitive potassium channels in longitudinal smooth muscle cells of rabbit jejunum

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Authors

CBChristopher D. BenhamUniversity of Leeds TBT. B. BoltonElectrophysiology

Discussion

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Implication

Experimental studies investigate potassium channels' activity and properties in rabbit jejunum smooth muscle cells, indicating their role in muscle electrical activity.

Key Points

This study aims to characterize the properties of potassium channels in longitudinal smooth muscle cells of rabbit jejunum using the patch-clamp technique.
Utilized the patch-clamp technique to record single channel currents from cell-attached and isolated membrane patches.
Investigated channel conductance and responsiveness to changes in membrane potential by altering potassium gradients.
Analyzed the opening behaviors of potassium channels during depolarization and conducted statistical fittings on opening distributions.
Identified outward unit currents blocked by tetraethylammonium, indicating potassium ion movement.
Conductance was about 50 pS with varying channel openings, particularly increasing between -40 to +40 mV.
Detected no inward currents at potentials negative to EK and observed channel openings followed a binomial distribution, suggesting independent events.

Cite This Study

Benham et al. (1983) studied this question.

synapsesocial.com/papers/6a1e2dfdd7563bdf2e1fb198 https://doi.org/10.1113/jphysiol.1983.sp014774

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July 1, 1983The Journal of PhysiologyOpen Access

Patch‐clamp studies of slow potential‐sensitive potassium channels in longitudinal smooth muscle cells of rabbit jejunum

View Full Paper

Ask AI

Bookmark

Authors

CBChristopher D. BenhamUniversity of Leeds TBT. B. BoltonElectrophysiology

Discussion

Member takes

Implication

Experimental studies investigate potassium channels' activity and properties in rabbit jejunum smooth muscle cells, indicating their role in muscle electrical activity.

Key Points

This study aims to characterize the properties of potassium channels in longitudinal smooth muscle cells of rabbit jejunum using the patch-clamp technique.
Utilized the patch-clamp technique to record single channel currents from cell-attached and isolated membrane patches.
Investigated channel conductance and responsiveness to changes in membrane potential by altering potassium gradients.
Analyzed the opening behaviors of potassium channels during depolarization and conducted statistical fittings on opening distributions.
Identified outward unit currents blocked by tetraethylammonium, indicating potassium ion movement.
Conductance was about 50 pS with varying channel openings, particularly increasing between -40 to +40 mV.
Detected no inward currents at potentials negative to EK and observed channel openings followed a binomial distribution, suggesting independent events.

Cite This Study

Benham et al. (1983) studied this question.

synapsesocial.com/papers/6a1e2dfdd7563bdf2e1fb198 https://doi.org/10.1113/jphysiol.1983.sp014774

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