May 1, 2002AJP Renal Physiology

Properties of an inwardly rectifying K+ channel in the basolateral membrane of mouse TAL

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Population

Mouse cortical thick ascending limb (CTAL) cells

Design

Preclinical

Authors

MPMarc PaulaisCentre National de la Recherche Scientifique SLStéphane LourdelCentre National de la Recherche Scientifique JTJacques TeulonDélégation Paris 5

Discussion

Member takes

Implication

Characterizes a basolateral Kir channel in mouse CTAL; leaves open its role in human renal K+ handling and therapeutic targeting.

Structured PICO

Population

Mouse cortical thick ascending limb (CTAL) cells

Intervention

Patch-clamp technique with exposure to varying concentrations of Mg2+, Na+, spermine, and pH

Outcome

Electrophysiological properties of inwardly rectifying K+ channels (conductance, permeability, sensitivity to inhibitors and pH)surrogate

Identifies and characterizes an inwardly rectifying K+ channel that likely represents a major component of K+ conductance in the mouse CTAL basolateral membrane.

Cite This Study

Paulais et al. (2002) studied this question.

synapsesocial.com/papers/6a85135ab7cd3c76619dec5f https://doi.org/10.1152/ajprenal.00238.2001

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Properties of an inwardly rectifying K+ channel in the basolateral membrane of mouse TAL

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Properties of an inwardly rectifying K+ channel in the basolateral membrane of mouse TAL

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider