Key result
Frog proximal tubule cells contain at least two distinct K(+)-selective conductances (GBa and Gquin) that are regulated by ATP and may be involved in pump-leak coupling.
Population
Single proximal tubule cells isolated from frog kidney
Comparison
ATP (2 mM in pipette), Ba2+, and quinidine vs Absence of ATP or inhibitors
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether analogous ATP-regulated K+ conductances mediate pump-leak coupling in mammals.
Identifies two distinct ATP-regulated K+ conductances in frog proximal tubule cells, which may be involved in pump-leak coupling.
Robson et al. (1997) studied this question. ATP vs. Absence of ATP was evaluated on K(+)-selective conductances and ATP sensitivity. Frog proximal tubule cells contain at least two distinct K(+)-selective conductances (GBa and Gquin) that are regulated by ATP and may be involved in pump-leak coupling.
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