August 1, 1989Proceedings of the National Academy of SciencesOpen Access

Coordinated regulation of intracellular K+ in the proximal tubule: Ba2+ blockade down-regulates the Na+,K+-ATPase and up-regulates two K+ permeability pathways.

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Population

Proximal tubules

Comparison

Ba2+ blockade vs Control conditions

Design

Preclinical

Authors

BKBruce C. KoneTexas Medical Center HBHugh R. BradyUniversity College Dublin SGSteven R. GullansWesleyan University

Discussion

Member takes

Implication

Does not alter clinical electrolyte management; extends mechanistic models of proximal tubule K+ homeostasis in animals.

Structured PICO

Population

Proximal tubules

Intervention

Ba2+ blockade

Comparator

Control conditions

Outcome

Cell K+ content and Na+-K+ pump ratesurrogate

The proximal tubule maintains intracellular K+ homeostasis by the coordinated modulation of multiple K+ transport pathways, including the Na+-K+ pump and passive K+ leaks.

Cite This Study

Kone et al. (1989) studied this question.

synapsesocial.com/papers/6a8874dae0903042354dfb79 https://doi.org/10.1073/pnas.86.16.6431

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Coordinated regulation of intracellular K+ in the proximal tubule: Ba2+ blockade down-regulates the Na+,K+-ATPase and up-regulates two K+ permeability pathways.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Coordinated regulation of intracellular K+ in the proximal tubule: Ba2+ blockade down-regulates the Na+,K+-ATPase and up-regulates two K+ permeability pathways.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider