July 1, 1987AJP Cell Physiology

Measurement of Na+-K+ coupling ratio of Na+-K+-ATPase in rabbit proximal tubules

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Population

Rabbit renal proximal tubules

Comparison

Abrupt stimulation of Na+-K+-ATPase by stepping… vs Ouabain (10 M) inhibition; presence or absence…

Design

Preclinical

Authors

MAMalcolm J. AvisonVanderbilt University Medical Center SGSteven R. GullansWesleyan University TOTakashi OginoMedipolis Medical Research Institute

Discussion

Member takes

Implication

Supports constant ~3:2 Na:K coupling in tubules; leaves open human renal applicability.

Structured PICO

Population

Rabbit renal proximal tubules

Intervention

Abrupt stimulation of Na+-K+-ATPase by stepping extracellular K+ concentration from 0.1-0.3 mM to 0.5-5.2 mM at 25 degrees C

Comparator

Ouabain (10(-3) M) inhibition; presence or absence of Ba2+

Outcome

Na+-K+ coupling ratio of Na+-K+-ATPasesurrogate

The Na+-K+-ATPase coupling ratio in rabbit proximal tubules is approximately 1.5, remaining constant across various physiological gradients and pump rates.

Cite This Study

Avison et al. (1987) studied this question.

synapsesocial.com/papers/6a6f2aa25d37378ac1dc3daa https://doi.org/10.1152/ajpcell.1987.253.1.c126

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Measurement of Na+-K+ coupling ratio of Na+-K+-ATPase in rabbit proximal tubules

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Measurement of Na+-K+ coupling ratio of Na+-K+-ATPase in rabbit proximal tubules

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider