Single‐Molecule Kinetics of Two‐Step Divalent Cation Chelation

A double hug: Two half-chelating ligands were covalently attached within the lumen of a protein nanopore (see picture). By electrical recording, the formation of fully chelated Zn2+ ions was monitored at the single-molecule level, thus revealing the rate constants for the eight major steps in the process. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.