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November 30, 2010CirculationOpen Access

High Levels of Systemic Myeloperoxidase Are Associated With Coronary Plaque Erosion in Patients With Acute Coronary Syndromes

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Why the study?

Are systemic myeloperoxidase levels associated with coronary plaque erosion compared to plaque rupture in patients with acute coronary syndromes?

Population

25 consecutive patients with acute coronary syndromes, mean age 67±11 years, 60% male, plus 22 postmortem…

Comparison

Plaque erosion vs Plaque rupture

Design

Cross-sectional

Authors

GFGiuseppe FerranteMNMasataka NakanoFPFrancesco Prati

Discussion

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Overview

MPO may aid noninvasive identification of plaque erosion in ACS; hypothesis-generating and requires prospective validation before clinical use.

Key Points

  • This research aims to explore the relationship between myeloperoxidase levels and different coronary morphologies in acute coronary syndromes.
  • Twenty-five patients with acute coronary syndrome were enrolled.
  • Optical coherence tomography was used to classify lesions as ruptured or eroded.
  • Systemic myeloperoxidase and C-reactive protein levels were measured and compared.
  • Median myeloperoxidase level was significantly higher in patients with eroded plaques at 2500 ng/mL versus 707 ng/mL for ruptured plaques (P=0.001).
  • Myeloperoxidase-positive cell density was higher in eroded lesions with a median of 1584 cells/mm² compared to 579 cells/mm² for ruptured lesions (P=0.0012).
  • No significant difference was found in C-reactive protein levels between the groups (P=0.76).

Structured PICO

Are systemic myeloperoxidase levels associated with coronary plaque erosion compared to plaque rupture in patients with acute coronary syndromes?

P
Population
25 consecutive patients with acute coronary syndromes (13 NSTE-ACS, 12 STEMI), mean age 67±11 years, 60% male, plus 22 postmortem coronary specimens from sudden coronary death victims.
I
Intervention
Plaque erosion (identified by optical coherence tomography in living patients or histology in postmortem specimens)
C
Comparator
Plaque rupture
O
Outcome
Systemic levels of serum myeloperoxidase and density of myeloperoxidase-positive cells within thrombisurrogate

Systemic myeloperoxidase levels are significantly elevated in ACS patients with eroded culprit plaques compared to those with ruptured plaques, suggesting its potential as a specific biomarker for plaque erosion.

Cite This Study

Ferrante et al. (2010) studied this question.

synapsesocial.com/papers/69ff97a4e92f4a033c852e56https://doi.org/10.1161/circulationaha.110.955302
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