What question did this study set out to answer?

Review the molecular mechanisms by which dietary selenium and specific selenoproteins regulate inflammation and immune responses, and evaluate their therapeutic potential across various inflammatory diseases.

September 28, 2011Antioxidants and Redox Signaling

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

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Authors

ZHZhi HuangSun Yat-sen University ARAaron H. RoseBoston College PHPeter R. HoffmannUniversity of Hawaiʻi at Mānoa

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Implication

Comprehensive review demonstrates essential roles of selenium in regulating immune cell signaling, indicating complex dose-dependent therapeutic opportunities.

Key Points

Review the molecular mechanisms by which dietary selenium and specific selenoproteins regulate inflammation and immune responses, and evaluate their therapeutic potential across various inflammatory diseases.
Synthesized findings from in vitro cell culture and in vivo animal models alongside human physiological and clinical data.
Evaluated molecular signaling mechanisms, including redox signaling, oxidative stress, protein folding, and calcium flux.
Assessed clinical conditions including viral infections, autoimmunity, sepsis, allergic asthma, and chronic inflammatory diseases.
Selenium deficiency impairs immune cell activation, differentiation, and proliferation primarily via elevated oxidative stress, impaired protein folding, and altered calcium flux.
Individual selenoproteins critically orchestrate both the initiation of host immune defenses and the resolution of excessive chronic inflammation.
Supranutritional selenium supplementation exerts dose-dependent and sexually dimorphic effects on immune function, presenting both therapeutic benefits and potential adverse outcomes depending on disease context.

Cite This Study

Huang et al. (2011) studied this question.

synapsesocial.com/papers/69ff97ace4618ba4162d8485 https://doi.org/10.1089/ars.2011.4145

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Implication

Comprehensive review demonstrates essential roles of selenium in regulating immune cell signaling, indicating complex dose-dependent therapeutic opportunities.

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Discussion

Member takes

Implication

Key Points

Cite This Study

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Discussion

Member takes

Implication

Key Points

Cite This Study

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