Experimental study demonstrates high spatiotemporal monitoring of evoked neurochemical release in live rats, highlighting droplet mass spectrometry for tracking dynamic brain chemistry.
C-labeled internal standards to the droplet samples was used for improved quantification. Utility of the overall system was demonstrated by monitoring dynamic chemical changes evoked by microinjection of high potassium concentrations into the brain of live rats. The results showed stimulated neurochemical release with rise times of 15 s. This work demonstrates the potential of coupling microfabricated sampling probes to droplet-based mass spectrometric assays for studying chemical dynamics in a complex microenvironment at high spatiotemporal resolution.
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Ngernsutivorakul et al. (2018) studied this question.
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