Why the study?
Do non-steroidal anti-inflammatory drugs increase the risk of myocardial infarction and other cardiovascular events in patients?
Population
116,429 patients from 31 large scale randomized controlled trials
Comparison
Non-steroidal anti-inflammatory drugs vs Placebo or other non-steroidal anti-inflammatory…
Design
Meta-analysis
Follow-up
more than 115,000 patient years of follow-up
Authors
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NSAIDs require cardiovascular risk-based selection; confirms differential MI, stroke, and CV death hazards across agents.
Do non-steroidal anti-inflammatory drugs increase the risk of myocardial infarction and other cardiovascular events in patients?
Various NSAIDs are associated with increased risks of cardiovascular events, including myocardial infarction, stroke, and cardiovascular death, with naproxen appearing the least harmful.
Trelle et al. (2011) studied this question.
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