Reversibility makes the difference: 30 years after Staab reported the synthesis of the phenylene-acetylene macrocycle 1 in 4.6 % yield starting from a simple precursor (see scheme), these structures are now available in nearly 80 % yield, also from simple precursors.
No takes yet. Share an insight, caveat, or question.
Sigurd Höger (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: