Why the study?
Do axial VADs cause higher shear stress and hemolysis compared to centrifugal VADs?
Population
Computational models of three clinical ventricular assist devices (VADs) and two investigational VADs
Comparison
Axial VADs vs Centrifugal VADs
Design
Preclinical
Authors
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Raises hemolysis concerns for axial VADs; animal data leave open effects on human outcomes and device selection.
Do axial VADs cause higher shear stress and hemolysis compared to centrifugal VADs?
Computational fluid dynamics and in vitro testing demonstrate that axial VADs produce higher shear stress and hemolysis compared to centrifugal VADs.
Fraser et al. (2012) studied this question.
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