August 3, 2008European Heart JournalOpen Access

Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population

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Why the study?

Does measurement of apolipoprotein B and apolipoprotein A-I improve the prediction of coronary heart disease mortality compared to routine clinical lipid measurements in US adults?

Population

7,594 US adults from the Third National Health and Nutrition Examination Survey mortality study

Comparison

Apolipoprotein B and apolipoprotein A-I… vs Traditional cardiovascular risk factors and…

Design

Cohort

Follow-up

median 124 person-months

Authors

JSJusto Sierra‐JohnsonAmgen (United States)RFRachel M. FisherKarolinska Institutet ARA. Romero-CorralMayo Clinic

Discussion

Member takes

Implication

ApoB and apoB/apoA-I ratio may refine CHD mortality risk assessment; leaves open incremental value over routine lipids.

Structured PICO

Does measurement of apolipoprotein B and apolipoprotein A-I improve the prediction of coronary heart disease mortality compared to routine clinical lipid measurements in US adults?

Population

7,594 US adults (mean age 45 years; 3,881 men and 3,713 women) from the Third National Health and Nutrition Examination Survey mortality study

Intervention

Apolipoprotein B (apoB) and apolipoprotein A-I (apoA-I) measurements

Comparator

Traditional cardiovascular risk factors and clinical routine lipid measurements (total cholesterol, HDL-C, TC/HDL-C ratio)

Outcome

Coronary heart disease (CHD) mortalityhard clinical

Apolipoprotein B and the apoB/apoA-I ratio are superior to routine clinical lipid measurements in predicting coronary heart disease mortality independently of traditional cardiovascular risk factors.

Cite This Study

Sierra‐Johnson et al. (2008) studied this question.

synapsesocial.com/papers/69ffae6eb124fe5819859020 https://doi.org/10.1093/eurheartj/ehn347

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Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider