Does disopyramide improve heart failure symptoms and remain safe in patients with symptomatic obstructive hypertrophic cardiomyopathy treated for >5 years?
Disopyramide appears safe and effective for long-term (>5 years) symptom relief in a subgroup of patients with obstructive hypertrophic cardiomyopathy.
BACKGROUND: Disopyramide is used to treat heart failure symptoms in patients with obstructive hypertrophic cardiomyopathy (HCM) with known medium-term efficacy and safety, while long-term outcomes are unknown. METHODS AND RESULTS: =0.51). Ventricular tachyarrhythmias and left ventricular systolic dysfunction were uncommon (n=3 and n=1) and were not attributed to disopyramide. Death on disopyramide was exceedingly rare (n=3 5%) and non-HCM-related occurring at age ≥90 years. CONCLUSIONS: In patients with obstructive HCM, disopyramide is safe and effective at relieving heart failure symptoms from outflow obstruction in a subgroup of patients who were maintained on disopyramide for >5 years.
Massera et al. (Thu,) studied this question.