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August 1, 2002The Journal of ImmunologyOpen Access

The Importance of IL-1β and TNF-α, and the Noninvolvement of IL-6, in the Development of Monoclonal Antibody-Induced Arthritis

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Authors

TKTakashi KagariDaiichi Sankyo (Germany)HDHiromi DoiKyoto UniversityTSTakaichi ShimozatoDaiichi-Sankyo (Japan)

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Kagari et al. (2002) studied this question.

synapsesocial.com/papers/69ffbe01b124fe58198598c2https://doi.org/10.4049/jimmunol.169.3.1459
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  2. 2IL-1αβ Blockade Prevents Cartilage and Bone Destruction in Murine Type II Collagen-Induced Arthritis, Whereas TNF-α Blockade Only Ameliorates Joint Inflammation1999 · 402 citations
  3. 3In vivo effects of recombinant human interleukin-6 in primates: stimulated production of platelets1990 · 37 citations
  4. 4The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.1988 · 803 citations
  5. 5Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice1997 · 333 citations