What question did this study set out to answer?

Investigate the fine-scale temporal processes underlying resting-state functional connectivity by decomposing moment-to-moment activity cofluctuations at single-frame resolution.

October 22, 2020Proceedings of the National Academy of SciencesOpen Access

High-amplitude cofluctuations in cortical activity drive functional connectivity

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Investigate the fine-scale temporal processes underlying resting-state functional connectivity by decomposing moment-to-moment activity cofluctuations at single-frame resolution.
Decomposed resting-state functional connectivity using a temporal unwrapping method to evaluate frame-by-frame cofluctuations in blood oxygen level-dependent (BOLD) signals.
Compared network modular organization and connection weights against high- and low-amplitude cofluctuation frames during rest and movie-watching paradigms.
A small fraction of frames showing the strongest cofluctuation amplitude accounted for a significant fraction of variance in overall connection weights and network modular structure.
High-amplitude frames coincided with peak BOLD activity amplitudes, driven primarily by coordinated activity within the default mode and control networks.
Cofluctuation amplitudes synchronized across subjects during movie watching, with high-amplitude frames carrying rich individual-specific information and low-amplitude frames carrying little.

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Implication

Functional neuroimaging analysis reveals that brief high-amplitude cofluctuations drive overall functional connectivity in human brains, indicating modular networks depend on sparse temporal events.

Cite This Study

Esfahlani et al. (2020) studied this question.

synapsesocial.com/papers/69ffc2e1da5c1eb07f2d8828 https://doi.org/10.1073/pnas.2005531117

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Implication

Functional neuroimaging analysis reveals that brief high-amplitude cofluctuations drive overall functional connectivity in human brains, indicating modular networks depend on sparse temporal events.

High-amplitude cofluctuations in cortical activity drive functional connectivity

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Discussion

Implication

Cite This Study

High-amplitude cofluctuations in cortical activity drive functional connectivity

Key Points

Discussion

Implication

Cite This Study

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