Hemodynamic Determinants of Myocardial B-Type Natriuretic Peptide Release
Population
42 subjects with a broad spectrum of systolic and diastolic left ventricular dysfunction
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
End-systolic wall stress may predominate over diastolic load in BNP release; hypothesis-generating, needs prospective validation before clinical use.
Structured PICO
P
Population
42 subjects with a broad spectrum of systolic and diastolic left ventricular dysfunction
I
Intervention
Transthoracic echocardiography, right heart catheterization, and simultaneous BNP measurement in arterial and coronary sinus plasma
O
Outcome
Transcardiac BNP gradient and its correlation with hemodynamic parameterssurrogate
Left ventricular end-systolic wall stress, rather than diastolic load, appears to be the primary mechanical stimulus for cardiac BNP release.
Cite This Study
Maeder et al. (2010) studied this question.