Key result
In 326 patients with chronic heart failure, the molar transcardiac increase in NT-pro-BNP was lower than BNP, and renal impairment had a greater influence on plasma NT-pro-BNP than on BNP.
Population
326 consecutive patients with chronic heart failure, divided into two groups based on renal function.
Design
Cross-sectional
Authors
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Renal impairment may confound NT-proBNP more than BNP in chronic HF; leaves open differential biomarker utility in CKD pending prospective studies.
Observational (n=326)
Renal dysfunction exerts a greater influence on plasma NT-pro-BNP levels than on BNP levels in patients with chronic heart failure, which should be considered when interpreting these biomarkers.
Tsutamoto et al. (2007) conducted an observational in Chronic heart failure (n=326). Renal impairment (eGFR <60 mL/min) vs. eGFR ≥60 mL/min was evaluated on Transcardiac increase and plasma levels of BNP and NT-pro-BNP. In 326 patients with chronic heart failure, the molar transcardiac increase in NT-pro-BNP was lower than BNP, and renal impairment had a greater influence on plasma NT-pro-BNP than on BNP.
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