Key result
In asymptomatic patients with chronic kidney disease, plasma BNP level is relatively independent of glomerular filtration rate, whereas NT-proBNP level is independently and inversely associated with GFR.
Why the study?
Does GFR influence BNP and NT-proBNP levels differently in euvolemic CKD patients without cardiac disease?
Cross-Sectional (n=142)
Single-blind
No
Does GFR influence BNP and NT-proBNP levels differently in euvolemic CKD patients without cardiac disease?
Effect estimate: Unstandardized regression coefficient -0.035 (95% CI -0.046 to -0.023)
p-value: p=<0.00001
Unlike NT-proBNP, plasma BNP levels are relatively independent of GFR, making BNP a potentially more appropriate biomarker for screening cardiac dysfunction in CKD patients.
No takes yet. Share an insight, caveat, or question.
Supports preferring BNP over NT-proBNP for cardiac screening in CKD; hypothesis-generating and should not yet change practice.
Tagore et al. (2008) conducted a cross-sectional in Chronic Kidney Disease (n=142). Glomerular filtration rate (GFR) was evaluated on Independent association between GFR and NT-proBNP level (Unstandardized regression coefficient -0.035, 95% CI -0.046 to -0.023, p=<0.00001). In asymptomatic patients with chronic kidney disease, plasma BNP level is relatively independent of glomerular filtration rate, whereas NT-proBNP level is independently and inversely associated with GFR.
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