Why the study?
Do BNP and NT-proBNP correlate and predict mortality and cardiac hospitalization in outpatients with renal dysfunction?
Do BNP and NT-proBNP correlate and predict mortality and cardiac hospitalization in outpatients with renal dysfunction?
BNP and NT-proBNP are highly correlated and serve as useful prognostic tools for mortality and cardiac hospitalization in patients with chronic kidney disease, despite levels increasing as GFR declines.
May aid prognostication in CKD outpatients; leaves open incremental value over GFR in prospective cohorts.
This study compared the correlation and prognostic utility of B-type natriuretic peptide (BNP) and the N-terminal fragment of proBNP (NT-proBNP) in 171 outpatients with renal dysfunction. The NT-proBNP correlated well with BNP in all cases (r = 0.911; P ≤ .01), regardless of degree of renal impairment or type of left ventricular dysfunction. BNP and NT-proBNP concentrations (P < .005) and their ratios (P ≤ .01) increased as the glomerular filtration rate (GFR) declined, indicating a greater effect of GFR on NT-proBNP levels. Both natriuretic peptide levels were higher in patients with systolic dysfunction (P < .05) compared with patients with normal echocardiograms. In contrast, BNP and NT-proBNP levels were below the diagnostic cutoffs for congestive heart failure exacerbations in patients with normal heart function or diastolic dysfunction, with no statistical difference between these groups (P = .99). Both peptides are useful prognostic tools for predicting mortality and cardiac hospitalization in renal patients.
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Austin et al. (2006) studied this question.
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