Why the study?
What are the optimal cutoffs for BNP and NT-proBNP to diagnose systolic heart failure in patients with impaired kidney function?
Population
190 adults with estimated glomerular filtration rate <60 ml/min for ≥3 months, mean age 58 years, 67.4%…
Comparison
Measurement of BNP and NT-proBNP levels vs Patients with vs without systolic heart failure…
Design
Cross-sectional
Authors
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May warrant higher natriuretic peptide cutoffs for SHF diagnosis in CKD; hypothesis-generating and requires prospective validation.
What are the optimal cutoffs for BNP and NT-proBNP to diagnose systolic heart failure in patients with impaired kidney function?
BNP and NT-proBNP are elevated in kidney dysfunction even without heart failure, requiring higher cutoffs (300 pg/ml for BNP and 4502 pg/ml for NT-proBNP) for diagnosing systolic heart failure in this population.
Jafri et al. (2013) studied this question.
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