Key result
Declining eGFR independently predicted plasma NT-proBNP (β=-0.19; P=0.016) but not urinary NT-proBNP, suggesting increased levels in acute heart failure are related to cardiac secretion.
Why the study?
Does kidney dysfunction affect plasma and urinary NT-proBNP concentrations in patients with acute heart failure?
Cohort (n=138)
Does kidney dysfunction affect plasma and urinary NT-proBNP concentrations in patients with acute heart failure?
Effect estimate: β=-0.19
p-value: p=0.016
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In patients with acute heart failure, increased circulating NT-proBNP in the setting of kidney dysfunction is likely due to increased cardiac secretion rather than decreased renal clearance.
Manzano‐Fernández et al. (2010) conducted a cohort in Acute Heart Failure (n=138). Kidney dysfunction (declining eGFR) vs. Normal kidney function / higher eGFR was evaluated on Plasma and urinary NT-proBNP concentrations (β=-0.19, p=0.016). Declining eGFR independently predicted plasma NT-proBNP (β=-0.19; P=0.016) but not urinary NT-proBNP, suggesting increased levels in acute heart failure are related to cardiac secretion.
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