What is the clinical evidence from this study?

Study design: Review. Population: Myeloproliferative neoplasms. Intervention: Heart failure and pulmonary hypertension.

What question did this study set out to answer?

This review aims to explore the associations between myeloproliferative neoplasms and cardiovascular conditions like heart failure and pulmonary hypertension.

July 16, 2025JACC CardioOncologyOpen Access

Beyond Thrombosis: Pulmonary Hypertension and Heart Failure in Patients With Myeloproliferative Neoplasms

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Key result

HF and pulmonary hypertension frequently complicate myeloproliferative neoplasms in a bidirectional relationship.

Population

Patients with myeloproliferative neoplasms (MPNs)

Design

Review

Authors

OLOrly LeivaUniversity of Kentucky OLOlivia LiuUniversity of Kentucky AKAnthony KanelidisUniversity of Chicago

Discussion

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Implication

This review highlights the importance of recognizing and managing nonthrombotic cardiovascular complications, specifically heart failure and pulmonary hypertension, in patients with myeloproliferative neoplasms.

Key Points

This review aims to explore the associations between myeloproliferative neoplasms and cardiovascular conditions like heart failure and pulmonary hypertension.
Review of clinical and preclinical data on cardiovascular risks in patients with myeloproliferative neoplasms.
Examination of the pathophysiology linking MPNs, heart failure, and pulmonary hypertension.
Heart failure and pulmonary hypertension are prevalent in patients with myeloproliferative neoplasms, impacting cardiovascular outcomes.
Emerging evidence suggests a bidirectional relationship between these cardiovascular conditions and hematologic progression.

Structured PICO

Population

Patients with myeloproliferative neoplasms (MPNs)

Cite This Study

Leiva et al. (2025) conducted a review in Myeloproliferative neoplasms. Heart failure and pulmonary hypertension was evaluated. Heart failure and pulmonary hypertension are prevalent nonthrombotic complications in patients with myeloproliferative neoplasms, sharing a bidirectional relationship with hematologic progression.

synapsesocial.com/papers/69ffcb327e61d2a3f0c22f3f https://doi.org/10.1016/j.jaccao.2025.05.010

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Beyond Thrombosis: Pulmonary Hypertension and Heart Failure in Patients With Myeloproliferative Neoplasms

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Beyond Thrombosis: Pulmonary Hypertension and Heart Failure in Patients With Myeloproliferative Neoplasms

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider