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May 1, 1969Journal of Clinical InvestigationOpen Access

Cardiac hemodynamics in alcoholic patients with chronic liver disease and a presystolic gallop

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Why the study?

What are the cardiac hemodynamic responses to exercise in alcoholic patients with chronic liver disease and a presystolic gallop?

Population

10 male subjects with chronic liver disease and normal cardiovascular findings except for the presence of a…

Design

Case_series

Authors

LGLawrence GouldRutgers, The State University of New JerseyMSMahmood ShariffUnited States Department of Veterans AffairsMZMohammad ZahirAyub Medical College

Discussion

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Implication

May signal latent LV dysfunction unmasked by exercise in these patients; leaves open generalizability and clinical relevance pending validation.

Structured PICO

What are the cardiac hemodynamic responses to exercise in alcoholic patients with chronic liver disease and a presystolic gallop?

P
Population
10 male subjects with chronic liver disease (alcoholic patients) and normal cardiovascular findings except for the presence of a presystolic gallop
I
Intervention
Right and left heart catheterization at rest and during exercise
O
Outcome
Cardiac hemodynamics (left ventricular end-diastolic pressure, mean pulmonary artery pressure, stroke index) at rest and during exercisesurrogate

Alcoholic patients with chronic liver disease and a presystolic gallop exhibit abnormal cardiac hemodynamics during exercise, suggesting underlying impairment in left ventricular function despite normal resting hemodynamics.

Cite This Study

Gould et al. (1969) studied this question.

synapsesocial.com/papers/69ffcb337e61d2a3f0c22f57https://doi.org/10.1172/jci106044

Topics

Sermorelin
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of ethanol on cellular membrane potentials and contractility of isolated rat atrium1962 · 129 citations
  2. 2A Hemodynamic Study of Left Ventricular Aneurysm1967 · 299 citations