December 1, 1998Clinical Endocrinology

Screening for primary aldosteronism with a logistic multivariate discriminant analysis*

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Why the study?

Does a logistic multivariate discriminant analysis approach accurately screen for primary aldosteronism in hypertensive patients?

Population

574 selected hypertensive patients

Design

Cohort

Authors

GRGian Paolo RossiUniversity of Padua ERErmanno RossiAzienda Sanitaria Unità Locale di Reggio Emilia EPEdoardo PavanUnited States Nuclear Regulatory Commission

Discussion

Member takes

Implication

May aid Conn's adenoma screening in hypertension; hypothesis-generating and requires prospective validation before practice change.

Structured PICO

Does a logistic multivariate discriminant analysis approach accurately screen for primary aldosteronism in hypertensive patients?

Population

574 selected hypertensive patients (206 retrospectively evaluated with 32 having Conn's adenoma, 48 prospectively evaluated for validation with 13% prevalence of CA, and 320 referred hypertensives with 3.4% prevalence of CA)

Intervention

Logistic multivariate discriminant analysis (MDA) using supine plasma renin activity (sPRA), K+, and captopril-suppressed plasma aldosterone (cALDO) (Model B)

Outcome

Identification of Conn's adenoma (CA)surrogate

A logistic multivariate discriminant analysis using renin, potassium, and captopril-suppressed aldosterone provides high sensitivity and accuracy for screening primary aldosteronism in hypertensive patients.

Limitations

Did not provide a clear-cut discrimination of Conn's adenoma from idiopathic hyperaldosteronism

Cite This Study

Rossi et al. (1998) studied this question.

synapsesocial.com/papers/69ffcb467e61d2a3f0c22f7a https://doi.org/10.1046/j.1365-2265.1998.00608.x

View Full Paper

Ask AI

Bookmark

Screening for primary aldosteronism with a logistic multivariate discriminant analysis*

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Screening for primary aldosteronism with a logistic multivariate discriminant analysis*

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider