Impact of New-Onset Left Bundle Branch Block and Periprocedural Permanent Pacemaker Implantation on Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement
Why the study?
Does new-onset LBBB or periprocedural PPI post-TAVR increase mortality or the need for PPI at 1 year in patients undergoing TAVR?
Population
Patients undergoing transcatheter aortic valve replacement from 17 studies.
Comparison
New-onset left bundle branch block or… vs Patients without new-onset LBBB or without…
Design
Meta-analysis
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
New-onset LBBB post-TAVR may warrant closer surveillance for PPI and cardiac death; extends pooled evidence on associated risks.
Structured PICO
Does new-onset LBBB or periprocedural PPI post-TAVR increase mortality or the need for PPI at 1 year in patients undergoing TAVR?
P
Population
Patients undergoing transcatheter aortic valve replacement (TAVR) from 17 studies (4,756 patients across 8 studies for LBBB evaluation and 7,032 patients across 11 studies for PPI evaluation).
I
Intervention
New-onset left bundle branch block (LBBB) or periprocedural permanent pacemaker implantation (PPI) post-TAVR
C
Comparator
Patients without new-onset LBBB or without periprocedural PPI post-TAVR
O
Outcome
Cardiac mortality, all-cause mortality, and need for PPI at 1-year follow-uphard clinical
New-onset LBBB post-TAVR is a marker for increased risk of cardiac death and subsequent need for PPI at 1 year, while periprocedural PPI does not increase 1-year mortality.
Cite This Study
Regueiro et al. (2016) studied this question.